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9	9	* The company recently acquire Imago BioSciences
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13	13	[[image:MRK0.webp||height="326" width="722"]]
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48	48	Worldwide sales were $59.3 billion in 2022, an increase of 22% compared with 2021, or 26% excluding the unfavorable effect of foreign exchange. The sales increase was primarily due to growth in virology (driven by the benefit of Lagevrio sales), oncology, vaccines and hospital acute care.
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51		-Cost of sales was $17.4 billion in 2022 and $13.6 billion in 2021. Cost of sales includes $3.0 billion and $502 million in 2022 and 2021, respectively, related to the collaboration with Ridgeback for Lagevrio (see Note 5 to the consolidated financial statements).
	50	+Cost of sales was $17.4 billion in 2022 and $13.6 billion in 2021. Cost of sales includes $3.0 billion and $502 million in 2022 and 2021, respectively, related to the collaboration with Ridgeback for Lagevrio.
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54	54	Gross margin was 70.6% in 2022 compared with 72.0% in 2021. Research and development (R&D) expenses were $13.5 billion in 2022, an increase of 11% compared with 2021. The effective income tax rates from continuing operations were 11.7% in 2022 and 11.0% in 2021.
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116	116	|(% style="width:170px" %)UK|(% style="width:143px" %) |(% style="width:208px" %) |(% style="width:166px" %)
117	117	|(% style="width:170px" %)Ukraine|(% style="width:143px" %) |(% style="width:208px" %) |(% style="width:166px" %)
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119		-
120	120	=== R&D facilities ===
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122	122	The company's Research facilities{{footnote}}https://www.merck.com/research/rd-locations/{{/footnote}}
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130	130	* Upper Gwynedd, PA - Site is headquarters for U.S. Human Health Division
131	131	* West Point, PA - Supports core discovery, preclinical and clinical functional areas — researching, manufacturing and testing pharmaceuticals and vaccines.
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134	134	=== Manufacturing & Supply locations in the U.S.{{footnote}}https://jobs.merck.com/us/en/manufacturing{{/footnote}} ===
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136	136	* Ames, IA
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144	144	* Wilson, NC
145	145	* Worthington, MN
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148	148	== Company History ==
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150	150	Merck & Co. was founded in the U.S. on January 1, 1891 by George Merck, to distribute fine chemicals throughout New York City and the neighboring areas.{{footnote}}https://www.merck.com/company-overview/history/{{/footnote}}
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181	181	|1998|(((
182	182	SINGULAIR approved by FDA
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184		-SINGULAIR (montelukast sodium) was approved by the FDA for the prevention and treatment of asthma. It was the product of nearly twenty years of research conducted at our Merck Frosst discovery hub in Kirkland, Canada, into a new class of asthma medicines called leukotriene blockers.
	180	+SINGULAIR (montelukast sodium) was approved by the FDA for the prevention and treatment of asthma. It was the product of nearly twenty years of research conducted at its Merck Frosst discovery hub in Kirkland, Canada, into a new class of asthma medicines called leukotriene blockers.
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186	186	|2004|Merck introduced Gardasil, a vaccine to prevent human papillomavirus (HPV), which can cause cervical cancer.
187	187	|2009|(((
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196	196	)))
197	197	|2020|Merck & Co., Inc. announced a collaboration with Ridgeback Biotherapeutics to develop a potential treatment for COVID-19.
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200	200	= References =
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202	202	{{putFootnotes/}}